Description

Position Summary

The Tadepalli Lab investigates how myeloid cells regulate immune outcomes during cancer therapy. Our research focuses on defining the molecular and functional heterogeneity of myeloid populations in response to radiotherapy and immunotherapy, and on leveraging this knowledge to engineer precision nanotherapeutics that reprogram their behavior.

By integrating molecular engineering with cancer immunology, we design nano-enabled therapeutics that modulate immune signaling and enhance crosstalk between myeloid and lymphoid cells. Our interdisciplinary research program spans immunology, nanotechnology, materials science, and molecular engineering, bringing together tools such as flow cytometry, animal models, and bio/nanomaterial synthesis. Our long-term goal is to establish mechanistic and translational understanding of radiation-induced immune responses and design nanotherapeutics for precision medicine.

We are seeking a highly motivated postdoctoral fellow to lead mechanistic and translational studies focused on how engineered nanomaterials can modulate myeloid cell function to improve radiotherapy and immunotherapy outcomes. The position involves:
• Designing and executing in vivo tumor and radiation experiments in murine models

• Performing high-dimensional immunophenotyping, transcriptomics, mouse colony management, and molecular biology assays

• Collaborating on nanomaterial synthesis and functionalization for targeted immune modulation

• Performing mechanistic assays to define immune activation and signaling pathways

• Preparing figures, manuscripts, and contributing to grant development

IUSM is committed to being a welcoming campus community and we seek candidates whose research, teaching, and community engagement efforts contribute to robust learning and working environments for all students, staff, and faculty. We invite individuals who will join us in our mission to improve health equity and well-being for all throughout the state of Indiana.

Basic Qualifications

Minimum Qualifications:

• PhD in Immunology, Cancer Biology, Biomedical Engineering, or a related discipline
• Demonstrated experience in mouse handling and tumor models or
nanomedicine/biomedical engineering
• Strong experimental design skills and a record of research productivity
• Excellent written and verbal communication abilities

Department Contact for Questions

Gerri Herron
HR Coordinator
geherron@iu.edu

Additional Qualifications

Preferred Qualifications:
• Background in cancer immunology or radiation immunotherapy
• Experience with multicolor flow cytometry and data analysis
• Familiarity with nanoparticle synthesis and characterization for biomedical applications
• Interest in multidisciplinary collaborations and mentoring